原创力文档saccharomyces cerevisiae population divergence and resistance to oxidative stress in clinical, domesticated and wild isolates酿酒酵母人口散度和抗氧化应激在临床,家养和野生隔离.pdfVIP
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saccharomyces cerevisiae population divergence and resistance to oxidative stress in clinical, domesticated and wild isolates酿酒酵母人口散度和抗氧化应激在临床,家养和野生隔离
Saccharomyces cerevisiae: Population Divergence and
Resistance to Oxidative Stress in Clinical, Domesticated
and Wild Isolates
Stephanie Diezmann*, Fred S. Dietrich
Department of Molecular Genetics Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
Abstract
Background: Saccharomyces cerevisiae has been associated with human life for millennia in the brewery and bakery.
Recently it has been recognized as an emerging opportunistic pathogen. To study the evolutionary history of S. cerevisiae,
the origin of clinical isolates and the importance of a virulence-associated trait, population genetics and phenotypic assays
have been applied to an ecologically diverse set of 103 strains isolated from clinics, breweries, vineyards, fruits, soil,
commercial supplements and insect guts.
Methodology/Principal Findings: DNA sequence data from five nuclear DNA loci were analyzed for population structure
and haplotype distribution. Additionally, all strains were tested for survival of oxidative stress, a trait associated with
microbial pathogenicity. DNA sequence analyses identified three genetic subgroups within the recombining S. cerevisiae
strains that are associated with ecology, geography and virulence. Shared alleles suggest that the clinical isolates contain
genetic contribution from the fruit isolates. Clinical and fruit isolates exhibit high levels of recombination, unlike the
genetically homogenous soil isolates in which no recombination was detected. However, clinical and soil isolates were more
resistant to oxidative stress than any other population, suggesting a correlation between survival in oxidative stress and
yeast pathogenicity.
Conclusions/Significance: Population genetic analyses of S. cerevisiae delineated three distinct groups, comprising prima
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