原创力文档s-adenosyl-methionine and betaine improve early virological response in chronic hepatitis c patients with previous nonresponses-adenosyl-methionine和甜菜碱提高早期病毒学反应在慢性丙型肝炎患者先前nonresponse.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
s-adenosyl-methionine and betaine improve early virological response in chronic hepatitis c patients with previous nonresponses-adenosyl-methionine和甜菜碱提高早期病毒学反应在慢性丙型肝炎患者先前nonresponse
S-Adenosyl-Methionine and Betaine Improve Early
Virological Response in Chronic Hepatitis C Patients with
Previous Nonresponse
1,2 1,2 3 1
Magdalena Filipowicz , Christine Bernsmeier , Luigi Terracciano , Francois H. T. Duong , Markus H.
Heim1,2*
1 Hepatology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland, 2 Department of Gastroenterology and Hepatology, University
Hospital Basel, Basel, Switzerland, 3 Institute for Pathology, University Hospital Basel, Basel, Switzerland
Abstract
Background/Aims: Treatment of chronic hepatitis C (CHC) with pegylated interferon a (pegIFNa) and ribavirin results in a
sustained response in approximately half of patients. Viral interference with IFNa signal transduction through the Jak-STAT
pathway might be an important factor underlying treatment failure. S-adenosyl-L-methionine (SAMe) and betaine
potentiate IFNa signaling in cultured cells that express hepatitis C virus (HCV) proteins, and enhance the inhibitory effect of
IFNa on HCV replicons. We have performed a clinical study with the aim to evaluate efficacy and safety of the addition of
SAMe and betaine to treatment of CHC with pegIFNa/ribavirin.
Methods: In this open-label pilot study, 29 patients with CHC who failed previous therapy with (peg)IFNa/ribavirin were
treated with SAMe, betaine, pegIFNa2b and ribavirin. Treatment duration was 6 or 12 months, depending on genotype, and
the protocol comprised a stopping rule at week 12 if early virological response (EVR) was not achieved. Virological and
biochemical response and safety were assessed throughout the treatment.
Results: 29 patients were enrolled and treated according to the
您可能关注的文档
- robust food anticipatory activity in bmal1-deficient mice健壮的食物先行活动bmal1-deficient老鼠.pdf
- robust network topologies for generating switch-like cellular responses健壮的网络拓扑生成开关类的细胞反应.pdf
- robust detection of hierarchical communities from escherichia coli gene expression data健壮的检测从大肠杆菌基因表达数据层次社区.pdf
- robust intrapulmonary cd8 t cell responses and protection with an attenuated n1l deleted vaccinia virus健壮的肺内的cd8 t细胞反应和保护具有减毒n1l牛痘病毒删除.pdf
- rnai-mediated silencing of paramyosin expression in trichinella spiralis results in impaired viability of the parasiternai-mediated paramyosin表达的沉默在旋毛虫结果受损的可行性的寄生虫.pdf
- rnf12 activates xist and is essential for x chromosome inactivationrnf12激活xist和x染色体失活是至关重要的.pdf
- robust models for optic flow coding in natural scenes inspired by insect biology鲁棒模型光学流编码在自然场景的灵感来自昆虫生物学.pdf
- robust time estimation reconciles views of the antiquity of placental mammals健壮的时间估计和解的古代胎盘类哺乳动物的观点.pdf
- robust signal processing in living cells强劲的信号处理在活细胞.pdf
- rock sparrow song reflects male age and reproductive success岩石麻雀之歌反映了男性的年龄和繁殖成功率.pdf
- saf-a forms a complex with brg1 and both components are required for rna polymerase ii mediated transcriptionsaf-a形式复杂的缺失和两个rna聚合酶ii介导转录所需组件.pdf
- saccharomyces cerevisiae as a model organism a comparative study酿酒酵母作为生物模型比较研究.pdf
- saccadic compression of rectangle and kanizsa figures now you see it, now you don't眼跳压缩矩形和kanizsa人物现在你看到它,现在你不喜欢.pdf
- safety and immunogenicity of a recombinant plasmodium falciparum ama1 malaria vaccine adjuvanted with alhydrogel？, montanide isa 720 or as02安全性和免疫原性的重组与alhydrogel ama1恶性疟原虫疟疾疫苗佐剂的,或as02 montanide isa 720.pdf
- safety and immunogenicity of an hiv adenoviral vector boost after dna plasmid vaccine prime by route of administration a randomized clinical trial艾滋病毒的安全性和免疫原性adenoviral向量提高质粒dna疫苗'后给药途径一个随机临床试验.pdf
- safety and immunogenicity of boosting bcg vaccinated subjects with bcg comparison with boosting with a new tb vaccine, mva85a提高bcg接种疫苗的安全性和免疫原性主题与bcg比较增加一个新的结核病疫苗,mva85a.pdf
- safe from harm learned, instructed, and symbolic generalization pathways of human threat-avoidance免受伤害,指示,象征人类threat-avoidance的推广途径.pdf
- safety and immunogenicity following administration of a live, attenuated monovalent 2009 h1n1 influenza vaccine to children and adults in two randomized controlled trials安全性和免疫原性管理现场后,减单价2009 h1n1流感疫苗对儿童和成人在两个随机对照试验.pdf
- safety and immunogenicity of rsh28gst antigen in humans phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasisrsh28gst的安全性和免疫原性抗原在人类第一阶段的随机临床研究对尿路血吸虫病的候选疫苗.pdf
- safety and immunogenicity of an ama1 malaria vaccine in malian children results of a phase 1 randomized controlled trialama1疟疾疫苗的安全性和免疫原性马里孩子第一阶段随机对照试验的结果.pdf
文档评论（0）