原创力文档safety and immunogenicity of an hiv adenoviral vector boost after dna plasmid vaccine prime by route of administration a randomized clinical trial艾滋病毒的安全性和免疫原性adenoviral向量提高质粒dna疫苗后给药途径一个随机临床试验.pdfVIP
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safety and immunogenicity of an hiv adenoviral vector boost after dna plasmid vaccine prime by route of administration a randomized clinical trial艾滋病毒的安全性和免疫原性adenoviral向量提高质粒dna疫苗后给药途径一个随机临床试验
Safety and Immunogenicity of an HIV Adenoviral Vector
Boost after DNA Plasmid Vaccine Prime by Route of
Administration: A Randomized Clinical Trial
1 2 3 3 3 3
Beryl A. Koblin *, Martin Casapia , Cecilia Morgan , Li Qin , Zhixue Maggie Wang , Olivier D. Defawe ,
4 5 6 6 3
Lindsey Baden , Paul Goepfert , Georgia D. Tomaras , David C. Montefiori , M. Juliana McElrath , Lilian
2 7 8
Saavedra , Chuen-Yen Lau , Barney S. Graham , The NIAID HIV Vaccine Trials Network
1 Laboratory of Infectious Disease Prevention, New York Blood Center, New York, New York, United States of America, 2 Asociacion Civil Selva Amazonica, Iquitos, Peru,
3 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 4 Brigham and Women’s Hospital,
Harvard Medical School, Boston, Massachusetts, United States of America, 5 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United
States of America, 6 Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America, 7 Division of Clinical Research, National
Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 8 Vaccine Research Center, National Institute of
Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Abstract
Background: In the development of HIV vaccines, improving immunogenicity while maintaining safety is critical. Route of
administration can be an important factor.
M
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