原创力文档safety and immunogenicity of the candidate tuberculosis vaccine mva85a in west africa候选结核病疫苗的安全性和免疫原性mva85a在西非.pdfVIP
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safety and immunogenicity of the candidate tuberculosis vaccine mva85a in west africa候选结核病疫苗的安全性和免疫原性mva85a在西非
Safety and Immunogenicity of the Candidate
Tuberculosis Vaccine MVA85A in West Africa
1 1 1 1 1
Roger H. Brookes , Philip C. Hill , Patrick K. Owiafe , Hannah B. Ibanga , David J. Jeffries , Simon A.
1 2 1 3 1
Donkor , Helen A. Fletcher , Abdulrahman S. Hammond , Christian Lienhardt , Richard A. Adegbola ,
Helen McShane2*, Adrian V. S. Hill2,4
1 Bacterial Diseases Programme, Tuberculosis Division, Medical Research Council Laboratories, Fajara, Banjul, The Gambia, 2 Centre for Clinical Vaccinology and Tropical
´
Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom, 3 Institut de Recherche pour le Developpement, Paris, France, 4 Wellcome Trust Centre for
Human Genetics, University of Oxford, Oxford, United Kingdom
Abstract
Background: Vaccination with a recombinant modified vaccinia Ankara expressing antigen 85A from Mycobacterium
tuberculosis, MVA85A, induces high levels of cellular immune responses in UK volunteers. We assessed the safety and
immunogenicity of this new vaccine in West African volunteers.
Methods and Findings: We vaccinated 21 healthy adult male subjects (11 BCG scar negative and 10 BCG scar positive) with
MVA85A after screening for evidence of prior exposure to mycobacteria. We monitored them over six months, observing for
clinical, haematological and biochemical adverse events, together with assessment of the vaccine induced cellular immune
res
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