safety and tolerability of lactobacillus reuteri dsm 17938 and effects on biomarkers in healthy adults results from a randomized masked trial这种乳酸菌的安全性和耐受性dsm 17938和影响生物标志物在健康成年人从随机的试验结果.pdfVIP
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safety and tolerability of lactobacillus reuteri dsm 17938 and effects on biomarkers in healthy adults results from a randomized masked trial这种乳酸菌的安全性和耐受性dsm 17938和影响生物标志物在健康成年人从随机的试验结果
Safety and Tolerability of Lactobacillus reuteri DSM
17938 and Effects on Biomarkers in Healthy Adults:
Results from a Randomized Masked Trial
1. 1. 1 2 1
Nisha Mangalat , Yuying Liu , Nicole Y. Fatheree , Michael J. Ferris , Melissa R. Van Arsdall ,
3 3,4 1 2 1
Zhongxue Chen , Mohammad H. Rahbar , Wallace A. Gleason , Johana Norori , Dat Q. Tran ,
J. Marc Rhoads1*
1 Department of Pediatrics, University of Texas Medical School at Houston, Houston, Texas, United States of America, 2 Department of Pediatrics, Louisiana State
University Health Science Center and The Research Institute for Children, New Orleans, Louisiana, United States of America, 3 Biostatistics/Epidemiology/Research Design
Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America, 4 Division of
Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health at Houston, Houston, Texas, United States of America
Abstract
Background: There are few carefully-designed studies investigating the safety of individual probiotics approved under
Investigational New Drug policies.
Objectives: The primary aim of this prospective, double-blind placebo-controlled trial was to investigate if daily treatment
of adults with Lactobacillus reuteri DSM 17938 (LR) for 2 months is safe and well-tolerated. Our secondary aim was to
determine if LR treatment has immune effects as determined by regulatory T cell per
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