role of 3′utrs in the translation of mrnas regulated by oncogenic eif4e—a computational inference翻译的作用3u2032utr mrna受致癌eif4e-a计算推理.pdfVIP

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role of 3′utrs in the translation of mrnas regulated by oncogenic eif4e—a computational inference翻译的作用3u2032utr mrna受致癌eif4e-a计算推理.pdf

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role of 3′utrs in the translation of mrnas regulated by oncogenic eif4e—a computational inference翻译的作用3u2032utr mrna受致癌eif4e-a计算推理

Role of 39UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference 1. 2. 3 4 4 Arti N. Santhanam , Eckart Bindewald , Vinagolu K. Rajasekhar , Ola Larsson , Nahum Sonenberg , 2 5 Nancy H. Colburn , Bruce A. Shapiro * 1 Gene Regulation Section, Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland, United States of America, 2 Basic Research Program, SAIC- Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America, 3 Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 4 Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada, 5 Center for Cancer Research, Nanobiology Program, National Cancer Institute, Frederick, Maryland, United States of America Abstract Eukaryotic cap-dependent mRNA translation is mediated by the initiation factor eIF4E, which binds mRNAs and stimulates efficient translation initiation. eIF4E is often overexpressed in human cancers. To elucidate the molecular signature of eIF4E target mRNAs, we analyzed sequence and structural properties of two independently derived polyribosome recruited mRNA datasets. These datasets originate from studies of mRNAs that are actively being translated in response to cells over- expressing eIF4E or cells with an activated oncogenic AKT: eIF4E signaling pathway, respectively. Comparison of eIF4E target mRNAs to mRNAs insensitive to eIF4E-regulation has revealed surprising features in mRNA secondary structure, length and microRNA-binding properties. Fold-changes