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revealing new mouse epicardial cell markers through transcriptomics通过转录组揭示新鼠标心外膜的细胞标记
Revealing New Mouse Epicardial Cell Markers through
Transcriptomics
1,2,3 2 3 1,4
Lars Bochmann *, Padmini Sarathchandra , Federica Mori , Enrique Lara-Pezzi , Domenico
Lazzaro3, Nadia Rosenthal1,2
1 Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Italy, 2 Harefield Heart Science Centre, Imperial College London, London, United Kingdom,
3 Istituto di Ricerche di Biologia Molecolare P. Angeletti SpA, Pomezia, Italy, 4 Cardiovascular Development Biology Department, Centro Nacional de Investigaciones
Cardiovasculares – CNIC, Madrid, Spain
Abstract
Background: The epicardium has key functions during myocardial development, by contributing to the formation of
coronary endothelial and smooth muscle cells, cardiac fibroblasts, and potentially cardiomyocytes. The epicardium plays a
morphogenetic role by emitting signals to promote and maintain cardiomyocyte proliferation. In a regenerative context, the
adult epicardium might comprise a progenitor cell population that can be induced to contribute to cardiac repair. Although
some genes involved in epicardial function have been identified, a detailed molecular profile of epicardial gene expression
has not been available.
Methodology: Using laser capture microscopy, we isolated the epicardial layer from the adult murine heart before or after
cardiac infarction in wildtype mice and mice expressing a transgenic IGF-1 propeptide (mIGF-1) that enhances cardiac
repair, and analyzed the transcription profile using DNA microarrays.
Principal Findings: Expression of epithelial genes such as basonuclin, dermokine, and glycoprotein M6A are highly enriched
in the epicardial layer, which maintains expression o
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