原创力文档role of ccl3l1-ccr5 genotypes in the epidemic spread of hiv-1 and evaluation of vaccine efficacyccl3l1-ccr5基因型在hiv - 1的流行病传播的作用和评价疫苗的功效.pdfVIP
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role of ccl3l1-ccr5 genotypes in the epidemic spread of hiv-1 and evaluation of vaccine efficacyccl3l1-ccr5基因型在hiv - 1的流行病传播的作用和评价疫苗的功效
Role of CCL3L1-CCR5 Genotypes in the Epidemic Spread
of HIV-1 and Evaluation of Vaccine Efficacy
1 2,3,4 2 5 1
Hemant Kulkarni *, Vincent C. Marconi , Brian K. Agan , Carole McArthur , George Crawford ,
Robert A. Clark1, Matthew J. Dolan3,4,6, Sunil K. Ahuja1,7*
1Veterans Administration Research Center for AIDS and HIV-1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, United States of America,
2 Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 3 Infectious Disease
Service, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas, United States of America, 4 San Antonio Military Medical Center, Fort Sam
Houston, Texas, United States of America, 5 Department of Oral Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, United States of
America, 6 Henry M. Jackson Foundation, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas, United States of America, 7 Department of
Medicine, Microbiology and Immunology and Biochemistry, University of Texas Health Science Center, San Antonio, Texas, United States of America
Abstract
Background: Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive
chemokine, are determinants of HIV-AIDS susceptibility. Here, we mathematically modeled the potential impact of these
genetic factors on the epidemic spread of HIV, as well as on its prevention.
Methods and Results: Ro, the basic reproductive number, is a fundamental concept in explaining the emergence and
persistence of epidemics. By modeling sexual transmission amo
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