原创力文档role of dlg5lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in llc-pk1 renal epithelial cellsdlg5lp-dlg作用,膜相关鸟苷激酶家族蛋白质,在epithelial-mesenchymal过渡llc-pk1肾上皮细胞.pdfVIP
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role of dlg5lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in llc-pk1 renal epithelial cellsdlg5lp-dlg作用,膜相关鸟苷激酶家族蛋白质,在epithelial-mesenchymal过渡llc-pk1肾上皮细胞
Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate
Kinase Family Protein, in Epithelial-Mesenchymal
Transition in LLc-PK1 Renal Epithelial Cells
1. 1. 1 1 1
Takuhito Sezaki , Kohki Inada , Takayuki Sogabe , Kumiyo Kakuda , Lucia Tomiyama ,
1 1 1 1,2 1
Yohsuke Matsuno , Takafumi Ichikawa , Michinori Matsuo , Kazumitsu Ueda , Noriyuki Kioka *
1 Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto, Japan, 2 Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto
University, Sakyo, Kyoto, Japan
Abstract
Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase adaptor family of proteins, some of
which are involved in the regulation of epithelial-to-mesenchymal transition (EMT). Dlg5 has been described as a
susceptibility gene for Crohn’s disease; however, the physiological function of Dlg5 is unknown. We show here that
transforming growth factor-b (TGF-b)-induced EMT suppresses Dlg5 expression in LLc-PK1 cells. Depletion of Dlg5
expression by knockdown promoted the expression of the mesenchymal marker proteins, fibronectin and a-smooth muscle
actin, and suppressed the expression of E-cadherin. In addition, activation of JNK and p38, which are stimulated by TGF-b,
was enhanced by Dlg5 depletion. Furthermore, inhibition of the TGF-b receptor suppressed the effects of Dlg5 depletion.
These observations suggest that Dlg5 is involved in the regulation of TGF- breceptor-dependent signal
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