revealing the functional neuroanatomy of intrinsic alertness using fmri methodological peculiarities揭示了功能性神经解剖学的内在警觉性使用fmri方法论的特点.pdfVIP

Revealing the Functional Neuroanatomy of Intrinsic Alertness Using fMRI: Methodological Peculiarities 1,2 2 3 3 1,2 Benjamin Clemens *, Mikhail Zvyagintsev , Alexander Sack , Armin Heinecke , Klaus Willmes , Walter Sturm4 1 Neurological Clinic, Section Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany, 2 Interdisciplinary Centre for Clinical Research – Neurofunctional Imaging Lab, University Hospital RWTH Aachen, Aachen, Germany, 3 Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands, 4 Neurological Clinic, Clinical Neuropsychology, University Hospital RWTH Aachen, Aachen, Germany Abstract Clinical observations and neuroimaging data revealed a right-hemisphere fronto-parietal-thalamic-brainstem network for intrinsic alertness, and additional left fronto-parietal activity during phasic alertness. The primary objective of this fMRI study was to map the functional neuroanatomy of intrinsic alertness as precisely as possible in healthy participants, using a novel assessment paradigm already employed in clinical settings. Both the paradigm and the experimental design were optimized to specifically assess intrinsic alertness, while at the same time controlling for sensory-motor processing. The present results suggest that the processing of intrinsic alertness is accompanied by increased activity within the brainstem, thalamus, anterior cingulate gyrus, right insula, and right parietal cortex. Additionally, we found increased activation in the left hemisphere around the middle frontal gyrus (BA 9), the insula, the supplementary motor area, and the cerebellum. Our