原创力文档repertoire of micrornas in epithelial ovarian cancer as determined by next generation sequencing of small rna cdna libraries的小分子核糖核酸在卵巢癌上皮由下一代测序的小rna互补脱氧核糖核酸数据库.pdfVIP
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repertoire of micrornas in epithelial ovarian cancer as determined by next generation sequencing of small rna cdna libraries的小分子核糖核酸在卵巢癌上皮由下一代测序的小rna互补脱氧核糖核酸数据库
Repertoire of microRNAs in Epithelial Ovarian Cancer as
Determined by Next Generation Sequencing of Small
RNA cDNA Libraries
2 2 2 2¤ 3
Stacia K. Wyman , Rachael K. Parkin , Patrick S. Mitchell , Brian R. Fritz , Kathy O’Briant , Andrew K.
4 3 3 3 1,2
Godwin , Nicole Urban , Charles W. Drescher , Beatrice S. Knudsen , Muneesh Tewari *
1 Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 2 Division of Human Biology, Fred Hutchinson
Cancer Research Center, Seattle, Washington, United States of America, 3 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle,
Washington, United States of America, 4 Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
Abstract
Background: MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently
shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which
improved outcomes could be achieved by successful early detection and enhanced understanding of molecular
pathogenesis that leads to improved therapies. A critical step toward these goals is to establish a comprehensive view of
miRNAs expressed in epithelial ovarian cancer tissues as well as in normal ovarian surface epithelial cells.
Methodology: We used massively parallel pyrosequencing (i.e., ‘‘454 sequencing’’) to discover and characterize novel and
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