原创力文档replication study in chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer复制在中国人口研究和荟萃分析支持协会的11个q23处与结直肠癌轨迹.pdfVIP
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replication study in chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer复制在中国人口研究和荟萃分析支持协会的11个q23处与结直肠癌轨迹
Replication Study in Chinese Population and Meta-
Analysis Supports Association of the 11q23 Locus with
Colorectal Cancer
1,2 2 2 2 1 1 3 2 2
Li Zou , Rong Zhong , Jiao Lou , Xuzai Lu , Qi Wang , Yang Yang , Jiahong Xia , Juntao Ke , Ti Zhang ,
2 4 5 1 1 1 1
Yu Sun , Li Liu , Yongping Cui , Haibing Xiao , Lei Chang , Ding Xia , Hua Xu *
1 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2 Department of Epidemiology and
Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,
China, 3 Department of Cardiovascular Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China, 4 Department of Epidemiology and
Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China, 5 Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi
Medical University, Taiyuan, Shanxi, China
Abstract
Background: A common single nucleotide polymorphism (SNP), rs3802842, located at 11q23, was identified by genome-
wide association studies (GWAS) to be significantly associated with the risk of colorectal cancer (CRC); however, the results
of following replication studies were not always concordant. Thus, a case-control study and a meta-analysis were performed
to clearly discern the effect of this variant in CRC.
Method and Findings: We determined the genotypes of rs3802842 in 641 unrelated Chinese patients with CRC and 1037
cancer-free controls. Additionally, a meta-analysis comprising current and previously publ
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