原创力文档regulation of gene expression with thyroid hormone in rats with myocardial infarction调节基因表达与甲状腺激素与心肌梗死大鼠.pdfVIP
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regulation of gene expression with thyroid hormone in rats with myocardial infarction调节基因表达与甲状腺激素与心肌梗死大鼠
Regulation of Gene Expression with Thyroid Hormone in
Rats with Myocardial Infarction
1 2 2 3 2 1
Yue-Feng Chen *, James V. Pottala , Nathan Y. Weltman , Xijin Ge , Olga V. Savinova , A. Martin Gerdes
1 Department of Biomedical Sciences, New York College of Osteopathic Medicine of New York Institute of Technology, Old Westbury, New York, United States of America,
2 Sanford Research/University of South Dakota, Sioux Falls, South Dakota, United States of America, 3 Department of Mathematics and Statistics, South Dakota State
University, Brookings, South Dakota, United States of America
Abstract
Introduction: The expression of hundreds of genes is altered in response to left ventricular (LV) remodeling following large
transmural myocardial infarction (MI). Thyroid hormone (TH) improves LV remodeling and cardiac performance after MI.
However, the molecular basis is unknown.
Methods: MI was produced by ligation of the left anterior descending coronary artery in female SD rats. Rats were divided
into the following groups: (1) Sham MI, (2) MI, and (3) MI+T4 treatment (T4 pellet 3.3 mg, 60 days release, implanted
subcutaneously immediately following MI). Four weeks after surgery, total RNA was isolated from LV non-infarcted areas for
microarray analysis using the Illumina RatRef-12 Expression BeadChip Platform.
Results: Signals were detected in 13,188 genes (out of 22,523), of which the expression of 154 genes were decreased and
the expression of 200 genes were increased in MI rats compared with Sham MI rats (false discovery rate (FDR) ,0.05).
Compared to MI rats, T4 treatment decreased expression of 27 genes and increased expression of 28 genes. In particular, 6
genes down-regulated by MI
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