原创力文档regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5监管的海马和行为兴奋性细胞周期蛋白依赖性激酶5.pdfVIP
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regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5监管的海马和行为兴奋性细胞周期蛋白依赖性激酶5
Regulation of Hippocampal and Behavioral Excitability
by Cyclin-Dependent Kinase 5
1 2 1 4 1,3
Ammar H. Hawasli , Della Koovakkattu , Kanehiro Hayashi , Anne E. Anderson , Craig M. Powell ,
2 1 5
Christopher M. Sinton , James A. Bibb *, Donald C. Cooper
1 Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 2 Department of Internal Medicine, University of
Texas Southwestern Medical Center, Dallas, Texas, United States of America, 3 Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas,
United States of America, 4 Departments of Pediatrics, Neurology and Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America, 5 Department
of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America
Abstract
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic
plasticity, neurotransmission, and numerous neurological disorders. We previously showed that conditional loss of Cdk5 in
adult mice enhanced hippocampal learning and plasticity via modulation of calpain-mediated N-methyl-D-aspartic acid
receptor (NMDAR) degradation. In the present study, we characterize the enhanced synaptic plasticity and examine the
effects of long-term Cdk5 loss on hippocampal excitability in adult mice. Field excitatory post-synaptic potentials (fEPSPs)
from the Schaffer collateral CA1 subregion of the hippocampus (SC/CA1) reveal that loss of Cdk5 a
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