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regulation of mariner transposition the peculiar case of mos1监管的水手换位mos1的特殊情况
Regulation of Mariner Transposition: The Peculiar Case of
Mos1
´ ˆ 1 1 1 2,3 ´ 1
Jerome Jaillet , Murielle Genty , Jeanne Cambefort , Jacques-Deric Rouault , Corinne Auge-Gouillou *
´ ´ ´ ´ ´
1 Innovation Moleculaire Therapeutique, EA 6306 – Universite Franc¸ois Rabelais, Parc Grandmont, Tours, France, 2 Laboratoire Evolution, Genomes et Speciation – CNRS
´
UPR9034, Gif-sur-Yvette, France, 3 Universite Paris-Sud 11, Orsay, France
Abstract
Background: Mariner elements represent the most successful family of autonomous DNA transposons, being present in
various plant and animal genomes, including humans. The introduction and co-evolution of mariners within host genomes
imply a strict regulation of the transposon activity. Biochemical data accumulated during the past decade have led to a
convergent picture of the transposition cycle of mariner elements, suggesting that mariner transposition does not rely on
host-specific factors. This model does not account for differences of transposition efficiency in human cells between
mariners. We thus wondered whether apparent similarities in transposition cycle could hide differences in the intrinsic
parameters that control mariner transposition.
Principal Findings: We find that Mos1 transposase concentrations in excess to the Mos1 ends prevent the paired-end
complex assembly. However, we observe that Mos1 transposition is not impaired by transposase high concentration,
dis
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