reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls降低疫苗的抗体反应在儿童暴露于多氯联苯.pdfVIP

PLoS MEDICINE Reduced Antibody Responses to Vaccinations in Children Exposed to Polychlorinated Biphenyls 1 2,3* ´ 2,4 2 2,5 Carsten Heilmann , Philippe Grandjean , Pal Weihe , Flemming Nielsen , Esben Budtz-Jørgensen 1 Paediatric Clinic II, National University Hospital, Rigshospitalet, Copenhagen, Denmark, 2 Institute of Public Health, University of Southern Denmark, Odense, Denmark, 3 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, 4 Department of Occupational Medicine and ´ Public Health, Torshavn, Faroe Islands, Denmark, 5 Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark Funding: This work was supported A B S T R A C T by the Danish Medical Research Council, the Danish Environmental Background Protection Agency as part of the environmental support program DANCEA (Danish Cooperation for Developmental exposure to polychlorinated biphenyls (PCBs) has been implicated as a Environment in the Arctic), the possible cause of deficient immune function in children. This study was designed to assess National Institute for Environmental whether prenatal and postnatal exposure to PCBs impacts on antibody response to childhood Health Sciences (ES 12199), and the U.S. Environmental Protection immunizations. Agency (R830758). The funders had no role in study design, data collection and analysis, decision to Methods and Findings publish, or preparation of the manuscript.