role of alpha-actinin-3 in contractile properties of human single muscle fibers a case series study in paraplegicsalpha-actinin-3的作用在人类单个肌肉纤维收缩性能的下身瘫痪的病例系列研究.pdfVIP

Role of Alpha-actinin-3 in Contractile Properties of Human Single Muscle Fibers: A Case Series Study in Paraplegics 1 4 4 3 1 Siacia Broos , Laurent Malisoux , Daniel Theisen , Marc Francaux , Louise Deldicque , Martine A. Thomis2* 1 Exercise Physiology Research Group, Department of Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Heverlee, Belgium, 2 Physical Activity, ´ ´ Sports and Health Research Group, Department of Kinesiology, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Heverlee, Belgium, 3 Faculte d’Education ´ ´ ´ ´ Physique et de Readaption, Faculte de Medecine, Universite Catholique de Louvain, Louvain-la-Neuve, Belgium, 4 Sports Medicine Research Laboratory, Public Research Center for Health, Grand-Duchy of Luxembourg, Luxembourg Abstract A common nonsense polymorphism in the ACTN3 gene results in the absence of a-actinin-3 in XX individuals. The wild type allele has been associated with power athlete status and an increased force output in numeral studies, though the mechanisms by which these effects occur are unclear. Recent findings in the Actn3 2/ 2 (KO) mouse suggest a shift towards ‘slow’ metabolic and contractile characteristics of fast muscle fibers lacking a-actinin-3. Skinned single fibers from the quadriceps muscle of three men with spinal cord injury (SCI) were tested regarding peak force, unloaded shortening