原创力文档safety, immunogenicity and duration of protection of the rts,sas02d malaria vaccine one year follow-up of a randomized controlled phase iiib trial安全、免疫原性和保护时间rts,sas02d疟疾疫苗一年随访的随机对照阶段希望审判.pdfVIP
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safety, immunogenicity and duration of protection of the rts,sas02d malaria vaccine one year follow-up of a randomized controlled phase iiib trial安全、免疫原性和保护时间rts,sas02d疟疾疫苗一年随访的随机对照阶段希望审判
Safety, Immunogenicity and Duration of Protection of
the RTS,S/AS02D Malaria Vaccine: One Year Follow-Up of
a Randomized Controlled Phase I/IIb Trial
Pedro Aide1,3*, John J. Aponte1,2, Montse Renom1,2, Tacilta Nhampossa1,3, Jahit Sacarlal 1,4, Inacio
1,3 1,2 ´ 1 5 5
Mandomando , Quique Bassat , Maria Nelia Manaca , Amanda Leach , Marc Lievens , Johan
5 5 6 5 5 1,2
Vekemans , Marie-Claude Dubois , Christian Loucq , W. Ripley Ballou , Joe Cohen , Pedro L. Alonso
˜ ´
1 Centro de Investigac¸ao em Saude da Manhic¸a (CISM), Maputo, Mozambique, 2 Barcelona Centre for International Health Research, Hospital Clinic, University of
´ ´ ´
Barcelona, Barcelona, Spain, 3 Instituto Nacional de Saude, Ministerio de Saude, Maputo, Mozambique, 4 Faculdade de Medicina, Universidade Eduardo Mondlane,
Maputo, Mozambique, 5 Glaxo-SmithKline Biologicals, Rixensart, Belgium, 6 PATH Malaria Vaccine Initiative, Bethesda, Maryland, United States of America
Abstract
Background: The RTS,S/AS02D vaccine has been shown to have a promising safety profile, to be immunogenic and to
confer protection against malaria in children and infants.
Methods and Findings: We did a randomized, controlled, phase I/IIb trial of RTS,S/AS02D given at 10, 14 and 18 weeks of
age staggered with routine immunization vaccines in 214 Mozambican infants. The study was double-blind until the young
child completed 6 months of follow-up over which period vaccine efficacy against new Plasmodium
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