safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence安全问题之间的自体脂肪移植,间充质干细胞与骨肉瘤复发.pdfVIP
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safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence安全问题之间的自体脂肪移植,间充质干细胞与骨肉瘤复发
Safety Concern between Autologous Fat Graft,
Mesenchymal Stem Cell and Osteosarcoma Recurrence
1,2,3 1,2 1,2,3 ´ 1,2 4
Pierre Perrot , Julie Rousseau , Anne-Laure Bouffaut , Franc¸oise Redini , Elisabeth Cassagnau ,
´ ´ 5, Marie-Franc¸oise Heymann1,2,4, Dominique Heymann1,2, Franck Duteille1,2,3,
Frederic Deschaseaux
´ 1,2, Franc¸ois Gouin1,2,6*
Valerie Trichet
´ ´ ´ ´
1 INSERM, U957, Nantes, France, 2 Universite de Nantes, Nantes Atlantique Universites, Laboratoire de Physiopathologie de la Resorption Osseuse et Therapie des
ˆ ´
Tumeurs Osseuses Primitives, EA3822, Nantes, France, 3 Centre Hospitalier Universitaire, Service de Chirurgie Plastique et des Brules, Nantes, France, 4 Centre Hospitalier
Universitaire, Service d’Anatomie Pathologique, Nantes, France, 5 Etablissement Franc¸ais du Sang Centre-Atlantique, EA3855, Tours, France, 6 Centre Hospitalier
´ ˆ ´
Universitaire, Service d’Orthopedie-Traumatologie, Pole Osteo-articulaire, Nantes, France
Abstract
Background: Osteosarcoma is the most common malignant primary bone tumour in young adult treated by neo adjuvant
chemotherapy, surgical tumor removal and adjuvant multidrug chemotherapy. For correction of soft tissue defect
consecutive to surgery and/or tu
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