sample size under inverse negative binomial group testing for accuracy in parameter estimation样本容量下逆负二项组测试参数估计的精度.pdfVIP

Sample Size under Inverse Negative Binomial Group Testing for Accuracy in Parameter Estimation ´ 1 ´ 2 ´ 3 4 Osval Antonio Montesinos-Lopez *, Abelardo Montesinos-Lopez , Jose Crossa *, Kent Eskridge ´ ´ ´ ´ ´ 1 Facultad de Telematica, Universidad de Colima, Colima, Colima, Mexico, 2 Departamento de Estadıstica, Centro de Investigacion en Matematicas (CIMAT), Guanajuato, ´ Guanajuato, Mexico, 3 Biometrics and Statistics Unit, Maize and Wheat Improvement Center (CIMMYT), Mexico D.F., Mexico, 4 Department of Statistics, University of Nebraska, Lincoln, Nebraska, United States of America Abstract Background: The group testing method has been proposed for the detection and estimation of genetically modified plants (adventitious presence of unwanted transgenic plants, AP). For binary response variables (presence or absence), group testing is efficient when the prevalence is low, so that estimation, detection, and sample size methods have been developed under the binomial model. However, when the event is rare (low prevalence ,0.1), and testing occurs sequentially, inverse (negative) binomial pooled sampling may be preferred. Methodology/Principal Findings: This research proposes three sample size procedures (two computational and one analytic) for estimating prevalence using group testing under inverse (negative) binomial sampling. These methods provide the required number of positive pools (rm ), given a pool size (k), for estimating the proportion of AP plants