sarcoidosis and tuberculosis cytokine profiles indistinguishable in bronchoalveolar lavage but different in blood结节病和结核病细胞因子资料无法区分在支气管肺泡灌洗,但不同的血液中.pdfVIP

Sarcoidosis and Tuberculosis Cytokine Profiles: Indistinguishable in Bronchoalveolar Lavage but Different in Blood 1 1 2 1 1 Muhunthan Thillai , Christian Eberhardt , Alex M. Lewin , Lee Potiphar , Suzie Hingley-Wilson , 1 1 3 3 4 Saranya Sridhar , Jonathan Macintyre , Onn Min Kon , Melissa Wickremasinghe , Athol Wells , 5 4 1 Mark E. Weeks , Donald Mitchell , Ajit Lalvani * 1 Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2 Biostatistics Group, Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom, 3 Department of Respiratory Medicine, St. Mary’s Hospital, London, United Kingdom, 4 Interstitial Lung Unit, Royal Brompton Hospital, Imperial College London NHS Healthcare Trust, London, United Kingdom, 5 Molecular Haematology and Cancer Biology Unit, UCL Institute of Child Health, London, United Kingdom Abstract Background: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. A complicating factor is that some cases of sarcoidosis may be initiated by mycobacteria. We hypothesised that immunological profiling might provide insight into a possible relationship between the diseases or allow us to distinguish between them. Methods: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n = 18), tuberculosis (n = 12) and healthy volunteers (n = 16). We further investigated serum samples in the same groups;