sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinomasarcopenia预测早期dose-limiting毒性和索拉非尼在肝细胞癌患者的药物动力学.pdfVIP
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sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinomasarcopenia预测早期dose-limiting毒性和索拉非尼在肝细胞癌患者的药物动力学
Sarcopenia Predicts Early Dose-Limiting Toxicities and
Pharmacokinetics of Sorafenib in Patients with
Hepatocellular Carcinoma
1,2 1,3 1,4 1
Olivier Mir *, Romain Coriat , Benoit Blanchet , Jean-Philippe Durand , Pascaline Boudou-
1 1 1 4 5 3
Rouquette , Judith Michels , Stanislas Ropert , Michel Vidal , Stanislas Pol , Stanislas Chaussade ,
Franc¸ois Goldwasser1
´
1 Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Universite Paris Descartes, Sorbonne Paris
´ ´ ´
Cite, Paris, France, 2 Department of Clinical Pharmacology, Cochin Teaching Hospital, AP-HP, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France, 3 Department of
´ ´
Gastro-Enterology, Cochin Teaching Hospital, AP-HP, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France, 4 Laboratory of Pharmacology and Toxicology, Cochin
´ ´
Teaching Hospital, AP-HP, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France, 5 Department of Hepatology and INSERM U1016, Cochin Teaching Hospital, AP-HP,
´ ´
Universite Paris Descartes, Sorbonne Paris Cite, Paris, France
Abstract
Background: Sorafenib induce
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