salivary gland transcriptomes and proteomes of phlebotomus tobbi and phlebotomus sergenti, vectors of leishmaniasis唾腺的转录组和蛋白质组phlebotomus tobbi和phlebotomus sergenti,向量的利什曼病.pdfVIP

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salivary gland transcriptomes and proteomes of phlebotomus tobbi and phlebotomus sergenti, vectors of leishmaniasis唾腺的转录组和蛋白质组phlebotomus tobbi和phlebotomus sergenti,向量的利什曼病.pdf

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salivary gland transcriptomes and proteomes of phlebotomus tobbi and phlebotomus sergenti, vectors of leishmaniasis唾腺的转录组和蛋白质组phlebotomus tobbi和phlebotomus sergenti,向量的利什曼病

Salivary Gland Transcriptomes and Proteomes of Phlebotomus tobbi and Phlebotomus sergenti, Vectors of Leishmaniasis ˇ ´ 1 2 ˇ ´ 1 3 1 Iva Rohousova , Sreenath Subrahmanyam , Vera Volfova , Jianbing Mu , Petr Volf , 2 2 Jesus G. Valenzuela *, Ryan C. Jochim * 1 Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 2 Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America, 3 Malaria Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Abstract Background: Phlebotomus tobbi is a vector of Leishmania infantum, and P. sergenti is a vector of Leishmania tropica. Le. infantum and Le. tropica typically cause visceral or cutaneous leishmaniasis, respectively, but Le. infantum strains transmitted by P. tobbi can cause cutaneous disease. To better understand the components and possible implications of sand fly saliva in leishmaniasis, the transcriptomes of the salivary glands (SGs) of these two sand fly species were sequenced, characterized and compared. Methodology/Principal Findings: cDNA libraries of P. tobbi and P. sergenti female SGs were constructed, sequenced, and analyzed. Clones (1,152) were randomly picked from each library, producing 1,142 high-quality sequences from P. tobbi and 1,090 from P. sergenti. The most abundant, secreted putative proteins were categorized as antigen 5-related proteins, apyrases, hyaluronidases, D7-related and PpSP15-l