sars transmission pattern in singapore reassessed by viral sequence variation analysissars传播模式在新加坡重新评估由病毒序列变异分析.pdfVIP

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sars transmission pattern in singapore reassessed by viral sequence variation analysissars传播模式在新加坡重新评估由病毒序列变异分析.pdf

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sars transmission pattern in singapore reassessed by viral sequence variation analysissars传播模式在新加坡重新评估由病毒序列变异分析

Open access, freely available online PLoS MEDICINE SARS Transmission Pattern in Singapore Reassessed by Viral Sequence Variation Analysis 1* 1 1 2 1 3 1 Jianjun Liu , Siew Lan Lim , Yijun Ruan , Ai Ee Ling , Lisa F. P. Ng , Christian Drosten , Edison T. Liu , 1 1 Lawrence W. Stanton , Martin L. Hibberd 1 Genome Institute of Singapore, Singapore, Singapore, 2 Department of Pathology, Singapore General Hospital, Singapore, 3 Bernhard Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg,Germany Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. ETL is a member of the Editorial Background Board of PLOS Medicine. Epidemiological investigations of infectious disease are mainly dependent on indirect Author Contributions: JL, ETL, LWS, and MLH designed the study. contact information and only occasionally assisted by characterization of pathogen sequence JL, SLL, and CD analyzed the data. variation from clinical isolates. Direct sequence analysis of the pathogen, particularly at a LFPN performed the experiments. population level, is generally thought to be too cumbersome, technically difficult, and YR coordinated sample acquiring and provided the genome sequence expensive. We present here a novel application of mass spectrometry (MS)–based technology variation data for designing MS in characterizing viral sequence variations that overcomes