原创力文档role of haptoglobin in polycystic ovary syndrome (pcos), obesity and disorders of glucose tolerance in premenopausal women结合珠蛋白在多囊卵巢综合症(pcos),肥胖和疾病的绝经前妇女的葡萄糖耐量.pdfVIP
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role of haptoglobin in polycystic ovary syndrome (pcos), obesity and disorders of glucose tolerance in premenopausal women结合珠蛋白在多囊卵巢综合症(pcos),肥胖和疾病的绝经前妇女的葡萄糖耐量
Role of Haptoglobin in Polycystic Ovary Syndrome
(PCOS), Obesity and Disorders of Glucose Tolerance in
Premenopausal Women
´ 1,2 a ´ ´ ´ 1,2 ´ 1,2 3
Francisco Alvarez-Blasco , M Angeles Martınez-Garcıa , Manuel Luque-Ramı rez , Naiara Parraza ,
´ ´ 2,4 ´ 1,2
Jose L. San Millan , Hector F. Escobar-Morreale *
´ ´ ´ ´
1 Department of Endocrinology, Hospital Universitario Ramon y Cajal Universidad de Alcala, Madrid, Spain, 2 Centro de Investigacion Biomedica en Red Diabetes y
´
Enfermedades Metabolicas Asociadas CIBERDEM, Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation, Madrid, Spain, 3 Department of Clinical
´ ´
Biochemistry, Hospital Universitario Ramon y Cajal, Madrid, Spain, 4 Department of Molecular Genetics, Hospital Universitario Ramon y Cajal, Madrid, Spain
Abstract
Background: Hp2 alleles of the haptoglobin a–chain polymorphism reduce the anti-oxidant properties and increase the pro-
inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin
polymorphism might contribute to the increased oxidative stress and low-grade chronic inflammation frequently associated
with polycystic ovary syndrome, obesity, and abn
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