reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation可逆的可塑性的恐惧记忆编码扁桃体突触回路即使恐惧记忆的巩固.pdfVIP

Reversible Plasticity of Fear Memory-Encoding Amygdala Synaptic Circuits Even after Fear Memory Consolidation 1 1 1 1 1 1 1 Ingie Hong , Jihye Kim , Junuk Lee , Sungmo Park , Beomjong Song , Jeongyeon Kim , Bobae An , 1 2 3 2 1 4 Kyungjoon Park , Hyun Woo Lee , Seungbok Lee , Hyun Kim , Sang-Hyun Park , Khee Dong Eom , 1 1 Sukwon Lee *, Sukwoo Choi * 1 School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea, 2 Division of Brain Korea 21 Biomedical Science, Department of Anatomy, College of Medicine, Korea University, Seoul, Korea, 3 Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, Seoul, Korea, 4 School of Biological Sciences, Nanyang Technological University, Singapore, Singapore Abstract It is generally believed that after memory consolidation, memory-encoding synaptic circuits are persistently modified and become less plastic. This, however, may hinder the remaining capacity of information storage in a given neural circuit. Here we consider the hypothesis that memory-encoding synaptic circuits still retain reversible plasticity even after memory consolidation. To test this, we employed a protocol of auditory fear conditioning which recruited the vast majority of the thalamic input synaptic circuit to the lateral amygdala (T-LA synaptic circuit; a storage site for fear memory) with fear conditioning-induced synaptic plasticity. Subsequently the fear memory-encoding synaptic circuits were challenged with fear extinction a