safety and immunogenicity of the malaria vaccine candidate msp3 long synthetic peptide in 12–24 months-old burkinabe children疟疾疫苗的安全性和免疫原性候选人msp3长12 - 24仅有几个月的国内儿童的合成肽.pdfVIP
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safety and immunogenicity of the malaria vaccine candidate msp3 long synthetic peptide in 12–24 months-old burkinabe children疟疾疫苗的安全性和免疫原性候选人msp3长12 - 24仅有几个月的国内儿童的合成肽
Safety and Immunogenicity of the Malaria Vaccine
Candidate MSP3 Long Synthetic Peptide in 12–24
Months-Old Burkinabe Children
1,2 1 ´ 1 1 ´
Sodiomon B. Sirima *, Alfred B. Tiono , Alphonse Ouedraogo , Amidou Diarra , Andre Lin
´ 1 1 ´ ´ 1 ´ 1 1
Ouedraogo , Jean Baptiste Yaro , Esperance Ouedraogo , Adama Gansane , Edith C. Bougouma ,
´ 1 ´ 1 ´ 1,2 3 1
Amadou T. Konate , Youssouf Kabore , Abdoulaye Traore , Chilengi Roma , Issiaka Soulama , Adrian
4 5 ´ ´ 1
J. F. Luty , Simon Cousens , Issa Nebie
´
1 Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso, 2 Groupe de Recherche et d’Action en Sante, Ouagadougou, Burkina Faso,
3 African Malaria Network Trust, Dar es Salaam, Tanzania, 4 Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5 London School of Hygiene and
Tropical Medicine, London, United Kingdom
Abstract
Background: A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a
Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to achieve
parasite killing in vitro, while a phase Ib trial in semi-immune adult volunteers in Burkina Faso confirmed that the vaccine
was safe. Th
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