原创力文档safety and immunogenicity of boosting bcg vaccinated subjects with bcg comparison with boosting with a new tb vaccine, mva85a提高bcg接种疫苗的安全性和免疫原性主题与bcg比较增加一个新的结核病疫苗,mva85a.pdfVIP
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safety and immunogenicity of boosting bcg vaccinated subjects with bcg comparison with boosting with a new tb vaccine, mva85a提高bcg接种疫苗的安全性和免疫原性主题与bcg比较增加一个新的结核病疫苗,mva85a
Safety and Immunogenicity of Boosting BCG Vaccinated
Subjects with BCG: Comparison with Boosting with a
New TB Vaccine, MVA85A
1. 1. 1 1 2
Kathryn T. Whelan , Ansar A. Pathan , Clare R. Sander , Helen A. Fletcher , Ian Poulton , Nicola C.
3 1 1
Alder , Adrian V. S. Hill , Helen McShane *
1Jenner Institute, University of Oxford, Churchill Hospital, Oxford, United Kingdom, 2 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford,
United Kingdom, 3 Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Abstract
Objectives: To investigate the safety and immunogenicity of a booster BCG vaccination delivered intradermally in healthy,
BCG vaccinated subjects and to compare with a previous clinical trial where BCG vaccinated subjects were boosted with a
new TB vaccine, MVA85A.
Design: Phase I open label observational trial, in the UK. Healthy, HIV-negative, BCG vaccinated adults were recruited and
vaccinated with BCG. The primary outcome was safety; the secondary outcome was cellular immune responses to antigen
85, overlapping peptides of antigen 85A and tuberculin purified protein derivative (PPD) detected by ex vivo interferon-
gamma (IFN-c) ELISpot assay and flow cytometry.
Results and Conclusions: BCG revaccination (BCG-BCG) was well tolerated, and boosting of pre-existing PPD-specific T cell
responses was observed. However, when these results were compared with data from a previous clinical trial, where BCG
was boosted with MVA85A (BCG-MVA85A), MVA85A induced significantly higher levels (.2-fold) of antigen 85-specific
CD4+ T cells (both antigen and peptide pool responses) than boost
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