原创力文档selective deletion of pten in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons选择性删除pten在纹状体的多巴胺神经元导致营养效果和适应中带刺的投射神经元.pdfVIP
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selective deletion of pten in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons选择性删除pten在纹状体的多巴胺神经元导致营养效果和适应中带刺的投射神经元
Selective Deletion of PTEN in Dopamine Neurons Leads
to Trophic Effects and Adaptation of Striatal Medium
Spiny Projecting Neurons
1 2 1 1 1 1
Oscar Diaz-Ruiz , Agustin Zapata , Lufei Shan , YaJun Zhang , Andreas C. Tomac , Nasir Malik ,
3 ¨ 1
Fidel de la Cruz , Cristina M. Backman *
1 Cellular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America, 2 Behavioral Neuroscience
´
Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America, 3 Escuela Nacional de Ciencias Biologicas, Instituto
´
Politecnico Nacional, Mexico City, Mexico
Abstract
The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain
functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for
growth, proliferation and cell survival. Pten deletion in the mouse brain has revealed its role in controlling cell size and
number. In this study, we used Cre-loxP technology to specifically inactivate Pten in dopamine (DA) neurons (Pten KO mice).
The resulting mutant mice showed neuronal hypertrophy, and an increased number of dopaminergic neurons and fibers in
the ventral mesencephalon. Interestingly, quantitative microdialysis studies in Pten KO mice revealed no alterations in basal
DA extracellular levels or evoked DA release in the dorsal striatum, despite a significant increase in total DA tissue levels.
Str
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