原创力文档selective inhibition of type iii secretion activated signaling by the salmonella effector avraiii型分泌激活信号的选择性抑制沙门氏菌效应avra.pdfVIP
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selective inhibition of type iii secretion activated signaling by the salmonella effector avraiii型分泌激活信号的选择性抑制沙门氏菌效应avra
Selective Inhibition of Type III Secretion Activated
Signaling by the Salmonella Effector AvrA
´
Fangyong Du, Jorge E. Galan*
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
Abstract
Salmonella enterica utilizes a type III secretion system (TTSS) encoded in its pathogenicity island 1 to mediate its initial
interactions with intestinal epithelial cells, which are characterized by the stimulation of actin cytoskeleton reorganization
and a profound reprogramming of gene expression. These responses result from the stimulation of Rho-family GTPases and
downstream signaling pathways by specific effector proteins delivered by this TTSS. We show here that AvrA, an effector
protein of this TTSS, specifically inhibits the Salmonella-induced activation of the JNK pathway through its interaction with
MKK7, although it does not interfere with the bacterial infection-induced NF-kB activation. We also show that AvrA is
phosphorylated at evolutionary conserved residues by a TTSS-effector-activated ERK pathway. This interplay between
effector proteins delivered by the same TTSS highlights the remarkable complexity of these systems.
´
Citation: Du F, Galan JE (2009) Selective Inhibition of Type III Secretion Activated Signaling by the Salmonella Effector AvrA. PLoS Pathog 5(9): e1000595.
doi:10.1371/journal.ppat.1000595
Editor: C. Erec Stebbins, The Rockefeller University, United States of America
Received April 8, 2009; Accepted August 27, 2009; Published September 25, 2009
´
Copyright: 2009 Du, Galan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted
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