selective involvement of the amygdala in systemic lupus erythematosus选择性杏仁核参与系统性红斑狼疮.pdfVIP

PLoS MEDICINE Selective Involvement of the Amygdala in Systemic Lupus Erythematosus 1* 1 2 2 1 Bart J. Emmer , Jeroen van der Grond , Gerda M. Steup-Beekman , Tom W. J. Huizinga , Mark A. van Buchem 1 Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands Funding: Part of this work was A B S T R A C T supported by a grant of the Dutch Arthritis Foundation. The funders had no role in study design, data collection and analysis, decision to Background publish, or preparation of the manuscript. Antibodies specifically affect the amygdala in a mouse model of systemic lupus erythematosus (SLE). The aim of our study was to investigate whether there is also specific Competing Interests: The authors involvement of the amygdala in human SLE. have declared that no competing interests exist. Academic Editor: Betty Diamond, Methods and Findings Columbia University, United States of America We analyzed a group of 37 patients with neuropsychiatric SLE (NP-SLE), 21 patients with SLE, and a group of 12 healthy control participants with diffusion weighted imaging (DWI). In Citation: Emmer BJ, van der Grond G, Steup-Beekman GM, Huizinga addition, in a subset of eight patients, plasma was available to determine their anti-NMDAR TWJ, van Buchem MA (2006