原创力文档selective impairments of resting-state networks in minimal hepatic encephalopathy静息状态网络的选择性损伤最小的肝性脑病.pdfVIP
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selective impairments of resting-state networks in minimal hepatic encephalopathy静息状态网络的选择性损伤最小的肝性脑病
Selective Impairments of Resting-State Networks in
Minimal Hepatic Encephalopathy
1 1 . 2 3 4 1
Rongfeng Qi , Long Jiang Zhang * , Qiang Xu , Jianhui Zhong , Shengyong Wu , Zhiqiang Zhang ,
2 1 1 2 1 1 5 5
Wei Liao , Ling Ni , Zongjun Zhang , Huafu Chen , Yuan Zhong , Qing Jiao , Xingjiang Wu , Xinxin Fan ,
6 1 .
Yijun Liu , Guangming Lu *
1 Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu Province, China, 2 Key Laboratory for
NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Sichuan Province, China,
3 Department of Imaging Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, 4 Medical Imaging Institute
of Tianjin, Tianjin, China, 5 Department of General Surgery, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, Jiangsu Province, China,
6 Department of Psychiatry, University of Florida McKnight Brain Institute, Gainesville, Florida, United States of America
Abstract
Background: Minimal hepatic encephalopathy (MHE) is a neuro-cognitive dysfunction characterized by impairment in
attention, vigilance and integrative functions, while the sensorimotor function was often unaffected. Little is known, so far,
about the exact neuro-pathophysiological mechanisms of aberrant cognition function in this disease.
Methodology/Principal Findings: To investigate ho
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