原创力文档serum micrornas as biomarkers for hepatocellular carcinoma in chinese patients with chronic hepatitis b virus infection血清microrna作为肝细胞癌的生物标志物在中国慢性乙型肝炎病毒感染患者.pdfVIP
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serum micrornas as biomarkers for hepatocellular carcinoma in chinese patients with chronic hepatitis b virus infection血清microrna作为肝细胞癌的生物标志物在中国慢性乙型肝炎病毒感染患者
Serum MicroRNAs as Biomarkers for Hepatocellular
Carcinoma in Chinese Patients with Chronic Hepatitis B
Virus Infection
1. 2. 3 2 1 1
Peng Qi , Shu-qun Cheng , Hao Wang , Nan Li , Yue-feng Chen , Chun-fang Gao *
1 Department of Laboratory Medicine, Second Military Medical University, Eastern Hepatobiliary Hospital, Shanghai, China, 2 Department of Oncology Comprehensive
Treatment, Second Military Medical University, Eastern Hepatobiliary Hospital, Shanghai, China, 3 Department of Laboratory Medicine, Second Military Medical University,
Changzheng Hospital, Shanghai, China
Abstract
Background: MicroRNAs (miRNAs) have been shown to anticipate great cancer diagnostic potential. Recently, circulating
miRNAs have been reported as promising biomarkers for various pathologic conditions. The objective of this study was to
investigate the potential of serum miRNAs as novel biomarkers for hepatocellular carcinoma (HCC).
Methodology/Principal Findings: This study was divided into four phases: (I) Ten candidate serum miRNAs were detected
by using real-time RT-PCR, corresponding 10 HCC patients with chronic hepatitis B virus (HBV) infection and 10 age- and
sex-matched healthy subjects. (II) Marker validation by real-time RT-PCR on HBV patients with (n = 48) or without HCC
(n = 48), and healthy subjects (n = 24). (III) Marker detection by real-time RT-PCR in sera from another 14 HCC patients before
and 1 month after surgical resection. (IV) We examined the correlation between the expressions of candidate serum miRNAs
with clinical parameters of HCC patients. Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated
between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs betwe
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