severe hindrance of viral infection propagation in spatially extended hosts严重阻碍病毒感染传播的空间扩展主机.pdfVIP

Severe Hindrance of Viral Infection Propagation in Spatially Extended Hosts ´ ´ 1,2 ´ 2,3 4 4 Jose A. Capitan , Jose A. Cuesta , Susanna C. Manrubia , Jacobo Aguirre * ` ` 1 Departament d’Enginyeria Informatica i Matematiques, Universitat Rovira i Virgili, Tarragona, Spain, 2 Grupo Interdisciplinar de Sistemas Complejos (GISC), Madrid, Spain, ´ ´ ´ ´ ´ 3 Departamento de Matematicas, Escuela Politecnica Superior, Universidad Carlos III de Madrid, Leganes, Madrid, Spain, 4 Centro de Astrobiologıa, CSIC-INTA, Torrejon de Ardoz, Madrid, Spain Abstract The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the universality class of directed percolation. In addition, we use the fact