selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a ghanaian population选择遗传变异诱导炎性反应在不良环境条件下在加纳人口.pdfVIP

Selection for Genetic Variation Inducing Pro- Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population 1 1 2 1 3 Maris Kuningas , Linda May , Riin Tamm , David van Bodegom , Anita H. J. van den Biggelaar , 4 ¨ 5 6 7 2,8 Johannes J. Meij , Marijke Frolich , Juventus B. Ziem , Helena E. D. Suchiman , Andres Metspalu , P. Eline Slagboom7,9, Rudi G. J. Westendorp1,9* 1 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, 3 Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Perth, Australia, 4 Leyden Academy on Vitality and Ageing, Leiden, The Netherlands, 5 Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands, 6 School of Medicine and Health Sciences, University of Development Studies, Tamale, Ghana, 7 Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, 8 Estonian Genome Project of University of Tartu, Tartu, Estonia, 9 Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands Abstract Background: Chronic inflammation is involved in the pathogenesis of chronic age-associated, degenerative diseases. Pro- inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions. Methodology/Princi