sex- and age-related differences in morbidity rates of 2009 pandemic influenza a h1n1 virus of swine origin in japan性u2014u20142009年患病率和年龄差异甲型流感h1n1病毒的猪产地在日本.pdfVIP

Sex- and Age-Related Differences in Morbidity Rates of 2009 Pandemic Influenza A H1N1 Virus of Swine Origin in Japan 1. 2 . 3 4 5 6 Nobuoki Eshima , Osamu Tokumaru * , Shohei Hara , Kira Bacal , Seigo Korematsu , Minoru Tabata , 7 8 8 7 Shigeru Karukaya , Yoshinori Yasui , Nobuhiko Okabe , Toyojiro Matsuishi 1 Department of Biostatistics, Oita University Faculty of Medicine, Yufu City, Oita, Japan, 2 Department of Neurophysiology, Oita University Faculty of Medicine, Yufu City, Oita, Japan, 3 The Yomiuri Shimbun Osaka (Newspaper), Osaka, Japan, 4 Medical Programme Directorate, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, 5 Department of Pediatrics, Oita University Faculty of Medicine, Yufu City, Oita, Japan, 6 Department of Mathematical Sciences, Graduate School of Engineering, Osaka Prefecture University, Sakai City, Osaka, Japan, 7 Department of Pediatrics, Kurume University School of Medicine, Kurume University, Kurume City, Fukuoka, Japan, 8 Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan Abstract Background: The objective of the present study was to determine whether the morbidity rates of the 2009 pandemic influenza A H1N1 virus (pdmH1N1) varied by age and/or sex. Methods and Findings: Retrospective analysis of 2,024,367 cases of pdmH1N1 was performed using the national surveillance data from influenza sentinel points in Japan. The male-to-female morbidity ratios (M/F ratios) in nineteen age groups were estimated as the primary outcome. The M/F ratios for pdmH1N1 influenza were: .