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sex and the single cell. ii. there is a time and place for sex性和单一细胞。
Sex and the Single Cell. II. There Is a Time and Place for
Sex
1¤ 1¤ 1,2¤ 1,2 ¤
Carmen C. Robinett , Alexander G. Vaughan , Jon-Michael Knapp , Bruce S. Baker *
1 Biology Department, Stanford University, Stanford, California, United States of America, 2 Neuroscience Program, Stanford University, Stanford, California, United States
of America
Abstract
The Drosophila melanogaster sex hierarchy controls sexual differentiation of somatic cells via the activities of the terminal
genes in the hierarchy, doublesex (dsx) and fruitless (fru). We have targeted an insertion of GAL4 into the dsx gene, allowing
us to visualize dsx-expressing cells in both sexes. Developmentally and as adults, we find that both XX and XY individuals are
fine mosaics of cells and tissues that express dsx and/or fruitless (fruM), and hence have the potential to sexually differentiate,
and those that don’t. Evolutionary considerations suggest such a mosaic expression of sexuality is likely to be a property of
other animal species having two sexes. These results have also led to a major revision of our view of how sex-specific
functions are regulated by the sex hierarchy in flies. Rather than there being a single regulatory event that governs the
activities of all downstream sex determination regulatory genes—turning on Sex lethal (Sxl) RNA splicing activity in females
while leaving it turned off in males—there are, in addition, elaborate temporal and spatial transcriptional controls on the
expression of the terminal regulatory genes, dsx and fru. Thus tissue-specific aspects of sexual development are jointly
specified by post-transcriptional control by Sxl and by the transcriptional co
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