sexual inequality in tuberculosis性肺结核的不平等.pdfVIP

Research in Translation Sexual Inequality in Tuberculosis Olivier Neyrolles1,2*, Lluis Quintana-Murci3 ´ ´ 1 Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, 2 Universite de Toulouse, Universite Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, 3 Institut Pasteur, Human Evolutionary Genetics, CNRS, URA3012, Paris, France The Sex Bias in TB Cases May Be of Biological Significance Summary Points Tuberculosis (TB) claims over 1.7 N In most countries, tuberculosis (TB) notification is twice as high in men as in million lives throughout the world each women. year according to the most recent World N Although there is clear evidence that socioeconomic and cultural factors Health Organization (WHO) report [1]. leading to barriers in accessing health care may cause undernotification in Men seem to be more affected than women, particularly in developing countries, biological mechanisms may women, with a male/female ratio of actually account for a significant part of this difference between male and 1.960.6 for the worldwide case notifica- female susceptibility to TB. tion rate (Box 1; Figure 1) [1]. In some N The role of biological gender has been determined in a number of infectious countries this ratio may reach values as and noninfectious diseases. However, there is an absence of information on the high as 3 (4.7 in Armenia for instance), but