原创力文档sexually transmitted infections among hiv-1-discordant couples性传播感染hiv-1-discordant夫妇.pdfVIP
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sexually transmitted infections among hiv-1-discordant couples性传播感染hiv-1-discordant夫妇
Sexually Transmitted Infections among HIV-1-Discordant
Couples
1 4 2,3 1,2,3 4
Brandon L. Guthrie *, James N. Kiarie , Susan Morrison , Grace C. John-Stewart , John Kinuthia ,
William L. H. Whittington2, Carey Farquhar1,2
1 Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, 2 Department of Medicine, University of Washington, Seattle,
Washington, United States of America, 3 Department of Global Health, University of Washington, Seattle, Washington, United States of America, 4 Department of
Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya
Abstract
Introduction: More new HIV-1 infections occur within stable HIV-1-discordant couples than in any other group in Africa, and
sexually transmitted infections (STIs) may increase transmission risk among discordant couples, accounting for a large
proportion of new HIV-1 infections. Understanding correlates of STIs among discordant couples will aid in optimizing
interventions to prevent HIV-1 transmission in these couples.
Methods: HIV-1-discordant couples in which HIV-1-infected partners were HSV-2-seropositive were tested for syphilis,
chlamydia, gonorrhea, and trichomoniasis, and HIV-1-uninfected partners were tested for HSV-2. We assessed
sociodemographic, behavioral, and biological correlates of a current STI.
Results: Of 416 couples enrolled, 16% were affected by a treatable STI, and among these both partners were infected in
17% of couples. A treatable STI was found in 46 (11%) females and 30 (7%) males. The most prevalent infections were
trichomoni
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