原创力文档sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis性二态的调节体重动力学和脂肪组织脂解作用.pdfVIP
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sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis性二态的调节体重动力学和脂肪组织脂解作用
Sexual Dimorphic Regulation of Body Weight Dynamics
and Adipose Tissue Lipolysis
1 1 1 ¨ 1 2
Verena Benz , Mandy Bloch , Sami Wardat , Christian Bohm , Lukas Maurer ,
3 4 2 1
Shokoufeh Mahmoodzadeh , Petra Wiedmer , Joachim Spranger , Anna Foryst-Ludwig ,
Ulrich Kintscher1*
´ ¨
1 Center for Cardiovascular Research, Institute of Pharmacology, Charite-Universitatsmedizin Berlin, Berlin, Germany, 2 Department of Endocrinology, Diabetes, and
´ ¨ ´ ¨
Nutrition, Charite-Universitatsmedizin Berlin, Berlin, Germany, 3 Center for Cardiovascular Research, Institute of Gender in Medicine, Charite-Universitatsmedizin Berlin,
Berlin, Germany, 4 Genetics of Metabolic and Reproductive Disorders, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany
Abstract
Background: Successful reduction of body weight (BW) is often followed by recidivism to obesity. BW-changes including
BW-loss and -regain is associated with marked alterations in energy expenditure (EE) and adipose tissue (AT) metabolism.
Since these processes are sex-specifically controlled, we investigated sexual dimorphisms in metabolic processes during BW-
dynamics (gain-loss-regain).
Research Design: Obesity was induced in C57BL/6J male (m) and female (f) mice by 15 weeks high-fat diet (HFD) feeding.
Subsequently BW was reduced (-20%) by caloric restriction (CR) followed by adaptive feeding, and a regain-phase.
Measuremen
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