shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (acpa) – positive rheumatoid arthritis in three asian ethnic groups共享抗原决定基等位基因仍然是一个风险因素anti-citrullinated蛋白抗体(acpa)u2014u2014积极类风湿性关节炎在三个亚洲民族.pdfVIP

Shared Epitope Alleles Remain A Risk Factor for Anti- Citrullinated Proteins Antibody (ACPA) – Positive Rheumatoid Arthritis in Three Asian Ethnic Groups 1,2 1 2 ¨ 1 3,4 Too Chun-Lai , Leonid Padyukov *, Jasbir Singh Dhaliwal , Emeli Lundstrom , Abqariyah Yahya , Nor 4 1 3 1 5 Asiah Muhamad , Lars Klareskog , Lars Alfredsson , Per Tobias Larsson , Shahnaz Murad , for the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA) Study Group 1 Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2 Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia, 3 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 4 Epidemiology and Biostatistics Unit, Institute for Medical Research, Kuala Lumpur, Malaysia, 5 Institute for Medical Research, Kuala Lumpur, Malaysia Abstract Background: To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia. Methods: 1,079 rheumatoid arthritis patients and 1,470 healthy controls were included in the study. Levels of antibodies to citrullinated proteins (ACPA) and rheumatoid factors were assessed and the PCR-SSO method was used for HLA-DRB1 genotyping. Results: The proportion of ACPA positivity among Malay, Chinese and Indian rheumatoid arthritis patients were 62.9%, 65.2% and 68.6%, respectively. An increased fre