原创力文档shear stress modulation of il-1β-induced e-selectin expression in human endothelial cells剪切应力调制il-1β-induced e-selectin人类内皮细胞表达.pdfVIP
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shear stress modulation of il-1β-induced e-selectin expression in human endothelial cells剪切应力调制il-1β-induced e-selectin人类内皮细胞表达
Shear Stress Modulation of IL-1b-Induced E-Selectin
Expression in Human Endothelial Cells
Ryan B. Huang, Omolola Eniola-Adefeso*
Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America
Abstract
Background: Endothelial cells (ECs) are continuously exposed to hemodynamic forces imparted by blood flow. While it is
known that endothelial behavior can be influenced by cytokine activation or fluid shear, the combined effects of these two
independent agonists have yet to be fully elucidated.
Methodology: We investigated EC response to long-term inflammatory cues under physiologically relevant shear conditions
via E-selectin expression where monolayers of human umbilical vein ECs were simultaneously exposed to laminar fluid shear
and interleukin-1ß (shear-cytokine activation) in a parallel plate flow chamber.
¨
Results and Conclusion: Naıve ECs exposed to shear-cytokine activation display significantly higher E-selectin expression
for up to 24 hr relative to ECs activated in static (static-cytokine). Peak E-selectin expression occurred after 8–12 hr of
continuous shear-cytokine activation contrary to the commonly observed 4–6 hr peak expression in ECs exposed to static-
cytokine activation. Cells with some history of high shear conditioning exhibited either high or muted E-selectin expression
depending on the durations of the shear pre-conditioning and the ensuing shear-cytokine activation. Overall, the presented
¨
data suggest that a high laminar shear enhances acute EC response to interleukin-1ß in naıve or shear-conditioned ECs as
may be found in the pathological setting of isc
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