原创力文档selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat选择性5 -羟色胺再摄取抑制剂加强serotonin4受体受体激动剂的快速抗抑郁影响的老鼠.pdfVIP
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selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat选择性5 -羟色胺再摄取抑制剂加强serotonin4受体受体激动剂的快速抗抑郁影响的老鼠
Selective Serotonin Reuptake Inhibitors Potentiate the
Rapid Antidepressant-Like Effects of Serotonin4 Receptor
Agonists in the Rat
1 1 1 1,2 2
Guillaume Lucas *, Jenny Du , Thomas Romeas , Ouissame Mnie-Filali , Nasser Haddjeri , Graciela
˜ 1, Guy Debonnel3{
Pineyro
´ ´ ´ ´ ´
1 Department of Psychiatry, Centre de Recherche Fernand Seguin, Universite de Montreal, Montreal, Quebec, Canada, 2 EAC CNRS 3006, ISPB Universite de Lyon 1, Faculty
ˆ ´ ´ ´
of Pharmacy, Lyon, France, 3 Department of Psychiatry, Batiment de Recherche et de Formation, Universite McGill, Montreal, Quebec, Canada
Abstract
Background: We have recently reported that serotonin (5-HT ) receptor agonists have a promising potential as fast-acting
4 4
antidepressants. Here, we assess the extent to which this property may be optimized by the concomitant use of
conventional antidepressants.
Methodology/Principal Findings: We found that, in acute conditions, the 5-HT4 agonist prucalopride was able to
counteract the inhibitory effect of the selective serotonin reuptake inhibitors (SSRI) fluvoxamine and citalopram on 5-HT
´
neuron impulse flow, in Dorsal Raphe Nucleus (DRN) cells selected for their high (.1.8 Hz) basa
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