selective expression of kcns3 potassium channel α-subunit in parvalbumin-containing gaba neurons in the human prefrontal cortexkcns3钾通道的选择性表达α-subunit parvalbumin-containing gaba神经元的人类前额叶皮层.pdfVIP

Selective Expression of KCNS3 Potassium Channel a-Subunit in Parvalbumin-Containing GABA Neurons in the Human Prefrontal Cortex 1 ´ 2 1,3 1,3 2,4 Danko Georgiev , Guillermo Gonzalez-Burgos , Mitsuru Kikuchi , Yoshio Minabe , David A. Lewis , Takanori Hashimoto1,2* 1 Department of Psychiatry and Neurobiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan, 2 Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Research Center for Child Mental Development, Kanazawa University, Kanazawa, Ishikawa, Japan, 4 Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract The cognitive deficits of schizophrenia appear to be associated with altered cortical GABA neurotransmission in the subsets of inhibitory neurons that express either parvalbumin (PV) or somatostatin (SST). Identification of molecular mechanisms that operate selectively in these neurons is essential for developing targeted therapeutic strategies that do not influence other cell types. Consequently, we sought to identify, in the human cortex, gene products that are expressed selectively by PV and/or SST neurons, and that might contribute to their distinctive functional properties. Based on previously reported expression patterns in the cortex of mice and humans, we selected four genes: KCNS3, LHX6, KCNAB1, and PPP1R2, encoding K+ channel Kv9.3 modulatory a-subunit, LIM homeobox protein 6, K+ channel Kvb1 subunit, and protein phosphatase 1 regulatory subunit 2, respectively, and examined their colocalization with PV o