原创力文档selfish little circles transmission bias and evolution of large deletion-bearing mitochondrial dna in caenorhabditis briggsae nematodes自私的小圆圈传播偏见和演化的大型deletion-bearing秀丽briggsae线虫的线粒体dna.pdfVIP
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selfish little circles transmission bias and evolution of large deletion-bearing mitochondrial dna in caenorhabditis briggsae nematodes自私的小圆圈传播偏见和演化的大型deletion-bearing秀丽briggsae线虫的线粒体dna
Selfish Little Circles: Transmission Bias and Evolution of
Large Deletion-Bearing Mitochondrial DNA in
Caenorhabditis briggsae Nematodes
1 1 1 1 1 2
Katie A. Clark , Dana K. Howe , Kristin Gafner , Danika Kusuma , Sita Ping , Suzanne Estes ,
Dee R. Denver1*
1 Department of Zoology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon, United States of America, 2 Department of
Biology, Portland State University, Portland, Oregon, United States of America
Abstract
Selfish DNA poses a significant challenge to genome stability and organismal fitness in diverse eukaryotic lineages.
Although selfish mitochondrial DNA (mtDNA) has known associations with cytoplasmic male sterility in numerous
gynodioecious plant species and is manifested as petite mutants in experimental yeast lab populations, examples of selfish
mtDNA in animals are less common. We analyzed the inheritance and evolution of mitochondrial DNA bearing large
heteroplasmic deletions including nad5 gene sequences (nad5D mtDNA), in the nematode Caenorhabditis briggsae. The
deletion is widespread in C. briggsae natural populations and is associated with deleterious organismal effects. We studied
the inheritance patterns of nad5D mtDNA using eight sets of C. briggsae mutation-accumulation (MA) lines, each initiated
from a different natural strain progenitor and bottlenecked as single hermaphrodites across generations. We observed a
consistent and strong drive toward higher levels of deletion-bearing molecules in the heteroplasmic pool of mtDNA after
ten generations of bottlenecking. Our results demonstrate a uniform transmission bias whereby nad5D mtDNA accumulates
to
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