原创力文档self-regulation of candida albicans population size during gi colonization自律的白色念珠菌在胃肠道殖民人口规模.pdfVIP
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self-regulation of candida albicans population size during gi colonization自律的白色念珠菌在胃肠道殖民人口规模
Self-Regulation of Candida albicans
Population Size during GI Colonization
1¤a 1 1¤b 1 1¤c 2
Sarah Jane White , Ari Rosenbach , Paul Lephart , Diem Nguyen , Alana Benjamin , Saul Tzipori ,
3 1 1*
Malcolm Whiteway , Joan Mecsas , Carol A. Kumamoto
1 Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, United States of America, 2 Division of Infectious Diseases, Tufts University,
Grafton, Massachusetts, United States of America, 3 Genetics Group, Biotechnology Research Institute, National Research Council, Montreal, Quebec, Canada
Interactions between colonizing commensal microorganisms and their hosts play important roles in health and
disease. The opportunistic fungal pathogen Candida albicans is a common component of human intestinal flora. To
gain insight into C. albicans colonization, genes expressed by fungi grown within a host were studied. The EFH1 gene,
encoding a putative transcription factor, was highly expressed during growth of C. albicans in the intestinal tract.
Counterintuitively, an efh1 null mutant exhibited increased colonization of the murine intestinal tract, a model of
commensal colonization, whereas an EFH1 overexpressing strain exhibited reduced colonization of the intestinal tract
and of the oral cavity of athymic mice, the latter situation modeling human mucosal candidiasis. When inoculated into
the bloodstream of mice, both efh1 null and EFH1 overexpressing strains caused lethal infections. In contrast, other
mutants are attenuated in virulence following intravenous inoculation but exhibited normal levels of intestinal
colonization. Fi
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