原创力文档self-organizing mechanism for development of space-filling neuronal dendrites发展空间的神经元树突的自组织机制.pdfVIP
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self-organizing mechanism for development of space-filling neuronal dendrites发展空间的神经元树突的自组织机制
Self-organizing Mechanism for Development
of Space-filling Neuronal Dendrites
1¤* 2 1 3*
Kaoru Sugimura , Kohei Shimono , Tadashi Uemura , Atsushi Mochizuki
1 Graduate School of Biostudies, Kyoto University, Kyoto, Japan, 2 Department of Science, Kyoto University, Kyoto, Japan, 3 Division of Theoretical Biology, National Institute
for Basic Biology, Okazaki, Japan
Neurons develop distinctive dendritic morphologies to receive and process information. Previous experiments showed
that competitive dendro-dendritic interactions play critical roles in shaping dendrites of the space-filling type, which
uniformly cover their receptive field. We incorporated this finding in constructing a new mathematical model, in which
reaction dynamics of two chemicals (activator and suppressor) are coupled to neuronal dendrite growth. Our numerical
analysis determined the conditions for dendritic branching and suggested that the self-organizing property of the
proposed system can underlie dendritogenesis. Furthermore, we found a clear correlation between dendrite shape and
the distribution of the activator, thus providing a morphological criterion to predict the in vivo distribution of the
hypothetical molecular complexes responsible for dendrite elongation and branching.
Citation: Sugimura K, Shimono K, Uemura T, Mochizuki A (2007) Self-organizing mechanism for development of space-filling neuronal dendrites. PLoS Comput Biol 3(11):
e212. doi:10.1371/journal.pcbi.0030212
Introduction branches (Figure 1C) [11,14]. It should be noted that the
qualitatively same inhibitory dendro-dendritic interaction is
One of the primary interests in developmental biology is
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