semantic similarity in biomedical ontologies语义相似度的生物医学本体.pdfVIP

Review Semantic Similarity in Biomedical Ontologies 1 1 ´ ˜ 1 2 1 Catia Pesquita *, Daniel Faria , Andre O. Falcao , Phillip Lord , Francisco M. Couto 1 LaSIGE, Faculty of Sciences, University of Lisboa, Lisboa, Portugal, 2 School of Computing Science, Newcastle University, Newcastle-upon-Tyne, United Kingdom directly (through alignment algorithms), the same is not true of Abstract: In recent years, ontologies have become a their functional aspects. The difference is that sequences and mainstream topic in biomedical research. When biological structures have an objective representation and measurable entities are described using a common schema, such as an properties, whereas functional aspects have neither. This does ontology, they can be compared by means of their not mean that it is impossible to compare functional aspects, but annotations. This type of comparison is called semantic that to be compared they must be expressed in a common and similarity, since it assesses the degree of relatedness objective form. between two entities by the similarity in meaning of their annotations. The application of semantic similarity to The advent of automated sequencing has had deep repercus- biomedical ontologies is recent; nevertheless, several sions on knowledge representatio