原创力文档senescence is more important in the natural lives of long- than short-lived mammals衰老是自然的生命长,更重要的是比短暂的哺乳动物.pdfVIP
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senescence is more important in the natural lives of long- than short-lived mammals衰老是自然的生命长,更重要的是比短暂的哺乳动物
Senescence Is More Important in the Natural Lives of
Long- Than Short-Lived Mammals
Christopher Turbill*, Thomas Ruf
Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Austria
Abstract
Background: Senescence has been widely detected among mammals, but its importance to fitness in wild populations
remains controversial. According to evolutionary theories, senescence occurs at an age when selection is relatively weak,
which in mammals can be predicted by adult survival rates. However, a recent analysis of senescence rates found more age-
dependent mortalities in natural populations of longer lived mammal species. This has important implications to ageing
research and for understanding the ecological relevance of senescence, yet so far these have not been widely appreciated.
We re-address this question by comparing the mean and maximum life span of 125 mammal species. Specifically, we test
the hypothesis that senescence occurs at a younger age relative to the mean natural life span in longer lived species.
Methodology/Principal Findings: We show, using phylogenetically-informed generalised least squares models, a significant
log-log relationship between mean life span, as calculated from estimates of adult survival for natural populations, and
maximum recorded life span among mammals (R2 = 0.57, p,0.0001). This provides further support for a key prediction of
evolutionary theories of ageing. The slope of this relationship (0.353 60.052 s.e.m.), however, indicated that mammals with
higher survival rates have a mean life span representing a greater fraction of their potential maximum life span: the ratio of
maximum to mean life span decreased significantly from .10 in short-lived to ,1.5 in long-lived mammal species.
Conclusions/Significance: We interpret the ratio of maximum to mean life span to b
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