原创力文档semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor半成熟的血树突状细胞存在于导管胰腺腺癌患者由于炎性因子释放肿瘤.pdfVIP
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semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor半成熟的血树突状细胞存在于导管胰腺腺癌患者由于炎性因子释放肿瘤
Semi Mature Blood Dendritic Cells Exist in Patients with
Ductal Pancreatic Adenocarcinoma Owing to
Inflammatory Factors Released from the Tumor
1 ˚ 2,3 ¨ 4 4 5
Vegard Tjomsland , Anna Spangeus , Per Sandstrom , Kurt Borch , Davorka Messmer , Marie
Larsson5*
¨ ¨
1 Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden, 2 Division of Internal Medicine, Department
¨ ¨ ¨ ¨
of Endocrinology, Linkoping University, Linkoping, Sweden, 3 Department of Medical and Health Science, Linkoping University, Linkoping, Sweden, 4 Division of Surgery,
¨ ¨
Linkoping University, Linkoping, Sweden, 5 Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America
Abstract
Background: Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs
(PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Functional impairment of DCs in patients with pancreatic ductal adenocarcinoma (PDAC), may contribute to the poor
clinical outcome. The aim of this study was to examine the effects PDAC had on blood DCs and elucidate the underlying
mechanism responsible for the DC impairment.
Methodology/Principal Findings: We examined the systemic influence PDAC exerte
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